Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity

Summary Although intramuscular (i.m.) administration is the most commonly used route for licensed vaccines, subcutaneous (s.c.) delivery is being explored for several new vaccines under development. Here, we use rhesus macaques, physiologically relevant to humans, to identify the anatomical compartments and early immune processes engaged in the response to immunization via the two routes. Administration…

mRNA Vaccines — A New Era in Vaccinology

Abstract | mRNA vaccines represent a promising alternative to conventional vaccine approaches because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. However, their application has until recently been restricted by the instability and inefficient in vivo delivery of mRNA. Recent technological advances have now largely overcome these…

Racism Redlining Cities Global Warming

Groundbreaking research on the intersection of climate change and segregation reveals how racist banking practices banned by Congress 52 years ago continue to shape how black and lower-income Americans experience the effects of global warming. Among other things, researchers found that historical “redlining” of minority neighborhoods in more than 100 American cities has placed a heavier…

US ‘Losing Time’ Against Delta Variant, NIH Chief Says

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. As COVID-19 cases increase again in nearly all states, public health officials say the US needs to get ahead of the contagious Delta variant by vaccinating more people, according to CNN. Average vaccination rates continue to drop, yet case rates are going up…

Vitamin D for All Over 50s to Prevent Cancer Deaths?

Vitamin D supplementation for older healthy adults has been much debated. Recent attention has been focused on its potential for reducing the risk for and severity of COVID-19, but there is an older argument, boosted by recent evidence, for taking vitamin D to reduce deaths from cancer. The recent data come from three meta-analyses published in…

Is Aspirin Overused in Older Patients With Diabetes?

Millions of US adults aged 70 years and over previously advised to take aspirin for primary prevention would not now have it recommended for routine continued use — in particular those with diabetes at low risk of cardiovascular disease (CVD) — say the authors of a new study investigating trends in use of the medication. The cross-sectional study…

Biden Dealt Outbreak of Resistance

WASHINGTON — Two weeks after celebrating America’s near “independence” from the coronavirus, President Joe Biden is confronting the worrying reality of rising cases and deaths — and the limitations of his ability to combat the persistent vaccine hesitance responsible for the summer backslide. Cases of COVID-19 have tripled over the past three weeks, and hospitalizations…